Tigers vs Guardians Prediction 5/22/25 MLB Picks Today

The Cleveland Guardians and the Detroit Tigers meet Thursday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tigers vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will start Tanner Bibee here and Bibee is 3-4 with a 4.06 ERA and 35 strikeouts this season. In his last five starts against the Tigers, Bibee is 1-2 with a 4.67 ERA and 25 strikeouts. Jack Flaherty will get the start for the Tigers here and is 2-5 with a 4.44 ERA and 56 strikeouts this season. In his last five starts against the Guardians, Flaherty is 2-1 with a 1.11 ERA and 26 strikeouts.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their 5-1 win over the Minnesota Twins from Wednesday’s matchup to improve to 26-22 on the year. After this series, the Guardians will head home for a series against the Dodgers.

Guardians Snap Five-Game Losing Streak

Steven Kwan leads the Guardians with 60 hits as part of a .317 batting average and 4 home runs, 11 doubles and 17 RBIs. Kyle Manzardo has 32 hits with 5 doubles, 2 triples, 10 home runs and a team-high 26 RBIs as well this year. Gabriel Arias has 8 doubles but also 46 strikeouts and Manzardo has 45 strikeouts so far this season. Arias has also added 4 home runs and 20 RBIs and Jose Ramirez has chipped in 9 home runs and 24 RBIs.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Detroit Tigers Recap

The Detroit Tigers come into this game looking to add on to their 5-1 win over the St. Louis Cardinals last time out to improve to 33-17 on the year. After this series, the Tigers will welcome the San Francisco Giants to town for an interleague set.

Tigers Win 7 Of Their Last 9

Spencer Torkelson has 43 hits along with a .249 batting average including a team-high 12 home runs, 13 doubles and 39 RBIs. Kerry Carpenter also has 10 home runs and 22 RBIs while Riley Greene has 54 hits with 10 doubles, 12 home runs and 34 RBIs but also has a team-high 59 strikeouts as well this season. Dillon Dingler has 4 home runs and 18 RBIs and Zack McKinstry’s added 9 doubles, 3 triples, 2 home runs and 17 RBIs of his own along with 44 hits as well this season. Javier Baez had added 40 hits and 8 doubles as well as 6 home runs and 29 RBIs this season.

Why the Detroit Tigers will win

Detroit Tigers Player Prop Facts

Total Runs Facts

Tigers vs Guardians Prediction

I’m on the Tigers here. I just haven’t loved the form of Tanner Bibee on the road and Jack Flaherty has been a lot better at home this season as have the Tigers. Flaherty also has had a lot of success going back to last year against the Guardians, and I think this ends up being a win for the Tigers to start the series. Give me Detroit to draw first blood in this one.

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